Background / Aims: Obesity and its effects, including diabetes, are an obvious and major health problem in Counties Manukau. We think that much obesity is due to genes that are switched off or on soon after conception. We think these genes can be favourably helped by good nutrition. NiPPeR stands for Nutritional Intervention Preconception and During Pregnancy to Maintain Healthy Glucose Metabolism and Offspring Health.
Methods: We are seeing participants at rooms in Mangere and Grafton. Women need at least one month of nutritional supplement before they become pregnant. They have a glucose tolerance test before pregnancy, at 28 weeks pregnant and up to 6 months after delivery. We have extensive questionnaires for the women and collect samples of blood, urine, hair, buccal smears, skin swabs and stool from women, and cord blood, cord and placental samples from the baby. We also collect data and samples from the father. The samples will contribute to a very large biobank that will be maintained for at least 20 years. The same study is being conducted in UK and Singapore. All the women get the usually-recommended supplements in pregnancy (iron, folic acid, iodine, calcium, beta-carotene). Half the women will get additional vitamins B2, B6, B12, D and zinc, myo-inisotol (a fibre breakdown product) and a probiotic.
Results: This trial started in August 2015. We have recruiting more than 220 women and expect to reach our target of 600 by the end of 2016. We will follow each woman until she is pregnant or for one year.
Conclusions: Recruitment numbers are on target. We want to recruit enough Maori and Pacific women so we can be confident that the scientific findings apply to them.
The University of Auckland